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Concept information

Preferred term

autophagy

Type

  • Topic

Definition

  • Information The segregation and degradation of various cytoplasmic constituents via engulfment by multivesicular bodies; vacuoles; or autophagosomes and their digestion by lysosomes. It plays an important role in biological metamorphosis and in the removal of bone by osteoclasts. Defective autophagy is associated with various diseases, including neurodegenerative diseases and cancer.

Broader concept

Synonyms

  • autophagic cell death
  • autophagic programmed cell death
  • autophagocytosis
  • type 2 programmed cell death

In other languages

URI

https://lod.nal.usda.gov/nalt/206099

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