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NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Fields of Study
  2. proteins
  3. membrane proteins
  4. membrane glycoproteins
  5. integrins
  6. lymphocyte function-associated antigen-1
  1. Research, Technology, Methods
  2. proteins
  3. membrane proteins
  4. membrane glycoproteins
  5. integrins
  6. lymphocyte function-associated antigen-1
  1. Fields of Study
  2. antigens
  3. surface antigens
  4. differentiation antigens
  5. CD antigens
  6. lymphocyte function-associated antigen-1

Preferred term

lymphocyte function-associated antigen-1

Type

  • Chemical

Definition

  • Information An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A antigen comprises the alpha chain and the CD18 antigen (antigen, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-cells; B-cells; and granulocytes. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

    Source: Medical Subject Headings 2014

    Type: Concept definition

Broader concept

Synonyms

  • integrin alphaLbeta2
  • leukocyte function associated antigen-1
  • LFA-1 (lymphocyte function-associated antigen-1)

In other languages

URI

https://lod.nal.usda.gov/nalt/211305

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RDF/XML TURTLE JSON-LD Created 2/28/14, last modified 6/28/17