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NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Fields of Study
  2. phosphotransferases (kinases)
  3. protein kinases
  4. protein-tyrosine kinases
  5. receptor protein-tyrosine kinase
  6. erbB-2 receptor
  1. Research, Technology, Methods
  2. phosphotransferases (kinases)
  3. protein kinases
  4. protein-tyrosine kinases
  5. receptor protein-tyrosine kinase
  6. erbB-2 receptor

Preferred term

erbB-2 receptor

Type

  • Chemical

Definition

  • Information A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (epidermal growth factor receptor), the erbB-3 receptor and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.

    Source: Medical Subject Headings 2014

    Type: Concept definition

Broader concept

Synonyms

  • c-erbB-2 protein
  • c-erbB2 receptor
  • c-neu proto-oncogene protein
  • erbB-2 proto-oncogene protein
  • erbB-2 receptor protein-tyrosine kinase
  • HER-2 proto-oncogene protein
  • human epidermal growth factor receptor-2
  • neu receptor
  • proto-oncogene protein c-neu
  • proto-oncogene protein HER-2
  • proto-oncogene proteins c-erbB-2

In other languages

URI

https://lod.nal.usda.gov/nalt/222856

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RDF/XML TURTLE JSON-LD Created 7/25/14, last modified 12/10/15