Concept information
- Research, Technology, Methods
- proteins
- membrane proteins
- G-protein coupled receptors
- chemokine receptors
Preferred term
CCR1 receptor
Type
-
Chemical
Definition
-
Chemokine (C-C Motif) Receptor 1, encoded by the CCR1 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells (monocytes, macrophages, neutrophils and eosinophils) to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite.
Source: National Cancer Institute Thesaurus
Type: Concept definition
Broader concept
Synonyms
- C-C chemokine receptor type 1
- C-C CKR1 receptor
- CD191 antigen
- chemokine (C-C motif) receptor 1
- LD78 cytokine receptor
- macrophage inflammatory protein 1alpha receptor
- RANTES receptor
In other languages
-
Spanish
URI
https://lod.nal.usda.gov/nalt/243409
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