Concept information
- Research, Technology, Methods
- proteins
- membrane proteins
- G-protein coupled receptors
- chemokine receptors
Preferred term
CCR8 receptor
Type
-
Chemical
Definition
-
This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.
Broader concept
Synonyms
- CC chemokine receptor 8
- C-C chemokine receptor type 8
- CC-CKR8 receptor
- CDw198 antigen
- chemokine (C-C motif) receptor 8
- chemokine (C-C) receptor 8
- chemokine receptor CKRL1
- chemokine receptor CLR-L1
- chemokine receptor TER1
- CKR8 receptor
- GPR-CY6 (G-protein coupled receptor-CY6)
In other languages
-
Spanish
URI
https://lod.nal.usda.gov/nalt/243493
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