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NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Research, Technology, Methods
  2. drugs
  3. antineoplastic agents
  4. etoposide
  1. Research, Technology, Methods
  2. aromatic compounds
  3. phenolic compounds
  4. lignans
  5. podophyllotoxin
  6. etoposide
  1. Research, Technology, Methods
  2. polycyclic aromatic hydrocarbons
  3. naphthalenes
  4. tetrahydronaphthalenes
  5. podophyllotoxin
  6. etoposide
  1. Research, Technology, Methods
  2. polycyclic aromatic hydrocarbons
  3. naphthalenes
  4. tetrahydronaphthalenes
  5. podophyllotoxin
  6. etoposide
  1. Research, Technology, Methods
  2. polycyclic aromatic hydrocarbons
  3. naphthalenes
  4. tetrahydronaphthalenes
  5. podophyllotoxin
  6. etoposide

Preferred term

etoposide

Type

  • Chemical

Definition

  • Information A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

    Source: Medical Subject Headings 2015

    Type: Concept definition

Broader concept

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URI

https://lod.nal.usda.gov/nalt/262750

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RDF/XML TURTLE JSON-LD Created 10/7/15, last modified 2/10/16