Concept information
Preferred term
transient receptor potential channels
Type
-
Chemical
Definition
-
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with sensation is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a Drosophila mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. Ankyrin repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with tyrosine kinase or type C phospholipases.
Source: Medical Subject Headings 2016
Type: Concept definition
Broader concept
Narrower concepts
Synonyms
- transient receptor potential (TRP) channels
- TRP cation channels
- TRP membrane proteins
In other languages
URI
https://lod.nal.usda.gov/nalt/271059
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