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Concept information

Preferred term

transient receptor potential channels

Type

  • Chemical

Definition

  • Information A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with sensation is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a Drosophila mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. Ankyrin repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with tyrosine kinase or type C phospholipases.

Broader concept

Synonyms

  • transient receptor potential (TRP) channels
  • TRP cation channels
  • TRP membrane proteins

URI

https://lod.nal.usda.gov/nalt/271059

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