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NALT Full

Preferred term

up-and-down procedure (UDP)

Definition

This test is an alternative to the Median Lethal Dose (LD50) test in which animals are used for acute toxicity testing. Animals are dosed one at a time with a drug or toxic substance. If an animal survives, the dose for the next animal is increased; if it dies, the dose is decreased to determine toxicity level.
Source: Based upon Bruce R. D. (1985). An up-and-down procedure for acute toxicity testing. Fundamental and applied toxicology : official journal of the Society of Toxicology, 5(1), 151–157.
Type: Concept definition

Broader concept

computational toxicology

In other languages

procedimiento de subida y bajada (UDP)

Spanish

URI

https://lod.nal.usda.gov/nalt/28890315

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