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NALT Completo

Preferred term

procedimiento de subida y bajada (UDP)

Definition

Prueba alternativa a la prueba de dosis letal media (LD50) en la que se utilizan animales para efectuar pruebas de toxicidad aguda. A estos se les administra de uno en uno una dosis de un fármaco o sustancia tóxica. Si un animal sobrevive, se aumenta la dosis para el siguiente; si muere, se reduce la dosis para determinar el nivel de toxicidad.
Source: Based upon Bruce R. D. (1985). An up-and-down procedure for acute toxicity testing. Fundamental and applied toxicology : official journal of the Society of Toxicology, 5(1), 151–157.
Type: https://lod.nal.usda.gov/naltv#Definition

Broader concept

toxicología computacional

In other languages

up-and-down procedure (UDP)

English

URI

https://lod.nal.usda.gov/nalt/28890315

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