Concept information
- Research, Technology, Methods
- proteins
- membrane proteins
- transport proteins
- signal transducing adaptor proteins
- Research, Technology, Methods
- proteins
- binding proteins
- transport proteins
- signal transducing adaptor proteins
Preferred term
insulin receptor substrate proteins
Type
-
Chemical
Definition
-
A structurally-related group of signaling proteins that are phosphorylated by the insulin receptor protein-tyrosine kinase. The proteins share an N-terminal pleckstrin homology domain, a phosphotyrosine-binding domain that interacts with the phosphorylated insulin receptor, and a C-terminal tyrosine-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 domain containing proteins that are involved in insulin receptor signaling.
Source: Medical Subject Headings 2017
Type: Concept definition
Broader concept
In other languages
URI
https://lod.nal.usda.gov/nalt/294108
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