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NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Fields of Study
  2. nucleases
  3. deoxyribonucleases
  4. endodeoxyribonucleases
  5. CRISPR-associated endonucleases
  6. CRISPR-associated endonuclease 9
  1. Research, Technology, Methods
  2. nucleases
  3. deoxyribonucleases
  4. endodeoxyribonucleases
  5. CRISPR-associated endonucleases
  6. CRISPR-associated endonuclease 9
  1. Fields of Study
  2. amino acids, peptides and proteins
  3. proteins
  4. CRISPR-associated proteins
  5. CRISPR-associated endonucleases
  6. CRISPR-associated endonuclease 9
  1. Research, Technology, Methods
  2. amino acids, peptides and proteins
  3. proteins
  4. CRISPR-associated proteins
  5. CRISPR-associated endonucleases
  6. CRISPR-associated endonuclease 9

Preferred term

CRISPR-associated endonuclease 9

Type

  • Chemical

Definition

  • Information An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand.

    Source: Taken in part from: Medical Subject Headings

    Type: Concept definition

Broader concept

Related concepts

Synonyms

  • Cas9 endonuclease
  • Cas9 enzyme
  • Cas9 protein

In other languages

URI

https://lod.nal.usda.gov/nalt/329081

Download this concept:

RDF/XML TURTLE JSON-LD Created 3/25/19, last modified 11/25/19