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NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Research, Technology, Methods
  2. drugs
  3. antilipemic agents
  4. anticholesteremic agents
  5. lovastatin
  6. simvastatin
  1. Research, Technology, Methods
  2. esters
  3. carboxylic esters
  4. fatty acid esters
  5. lovastatin
  6. simvastatin
  1. Research, Technology, Methods
  2. carbonyl compounds
  3. carboxylic esters
  4. fatty acid esters
  5. lovastatin
  6. simvastatin

Preferred term

simvastatin

Type

  • Chemical

Definition

  • Information A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl CoA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol.

    Source: Medical Subject Headings

    Type: Concept definition

Broader concept

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URI

https://lod.nal.usda.gov/nalt/341360

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RDF/XML TURTLE JSON-LD Created 7/15/20, last modified 10/29/20