Skip to main content
An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

NALT Concept Space
U.S. Department of Agriculture

NALT Full

Concept information

  1. Research, Technology, Methods
  2. drugs
  3. anti-infective agents
  4. antibiotics
  5. peptide antibiotics
  6. actinomycin D
  1. Fields of Study
  2. biochemical compounds
  3. amino acids, peptides and proteins
  4. peptides
  5. cyclic peptides
  6. actinomycin D
  1. Research, Technology, Methods
  2. biochemical compounds
  3. amino acids, peptides and proteins
  4. peptides
  5. cyclic peptides
  6. actinomycin D
  1. Research, Technology, Methods
  2. chemical substances
  3. chemical compounds
  4. organic compounds
  5. heterocyclic compounds
  6. actinomycin D
  1. Research, Technology, Methods
  2. drugs
  3. antineoplastic agents
  4. actinomycin D

Preferred term

actinomycin D

Type

  • Chemical

Definition

  • Information A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.

    Source: Medical Subject Headings 2011

    Type: Concept definition

Broader concept

Synonyms

  • dactinomycin

In other languages

URI

https://lod.nal.usda.gov/nalt/3814

Download this concept:

RDF/XML TURTLE JSON-LD Created 1/19/06, last modified 11/17/17