Concept information
Preferred term
prions
Type
-
Chemical
Definition
-
Small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc; the cellular isoform is PrPC. The primary amino acid sequence of the two isoforms is identical. Among diseases caused by prions are scrapie, bovine spongiform encephalopathy, and Creuzfeldt-Jakob Syndrome.
Source: Medical Subject Headings
Type: Concept definition
Broader concept
Narrower concepts
Synonyms
- prion proteins
- PrP proteins
In other languages
-
Spanish
URI
https://lod.nal.usda.gov/nalt/40965
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