@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:143748
  skos:broader nalt:46998 ;
  dc:created "2011-03-30"^^xsd:date ;
  skos:hiddenLabel "interferon alpha-1"@en, "interferon-alpha 2b"@en, "interferon-alpha 1a"@en, "interferon alpha-2"@en, "interferon-alpha 1"@en, "alpha interferons"@en, "interferon-alpha 2"@en ;
  skos:prefLabel "interferón-alfa"@es, "interferon-alpha"@en ;
  skos:altLabel "alpha interferon"@en, "alpha-interferon"@en, "interferon alpha-A"@en ;
  dc:modified "2020-03-02"^^xsd:date ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:definition nalt:143748_def ;
  ns0:marc001 "59814" .

nalt:143748_def
  rdf:value "El interferón producido por los linfocitos estimulados mitogénica o antigénicamente. Es estructuralmente diferente del interferón de tipo I y su actividad principal es la inmunorregulación. Se ha implicado en la expresión de antígenos de histocompatibilidad de clase II en las células que normalmente no los producen, lo que conduce a enfermedades autoinmunes."@es, "One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates natural killer cells and B-lymphocytes, and down-regulates vascular endothelial growth factor expression through PI-3 kinase and MAPK kinases signaling pathways."@en ;
  dc:source "Medical Subject Headings" ;
  a ns0:Definition .

ns0:Topic
  rdfs:label "Topic"@en ;
  a owl:Class .

nalt:46998
  skos:prefLabel "interferones"@es, "interferons"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:143748 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .