@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:219107_def
  rdf:value "Ubiquitina ligasa E3 que interviene principalmente en la regulación de la transición de la metafase a la anafase en la mitosis mediante la ubiquitinación de proteínas específicas del ciclo celular. La actividad enzimática es estrictamente regulada por medio de subunidades y cofactores que modulan la activación, la inhibición y la especificidad de los sustratos. El complejo promotor de la anafase (CPA) también participa en la diferenciación tisular en la placenta, los cristalinos y el músculo esquelético y en la regulación de la plasticidad y la excitabilidad neuronal posmitótica."@es, "An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during mitosis through ubiquitination of specific cell cycle proteins. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the placenta, crystalline lens, and skeletal muscle, and in regulation of postmitotic neuronal plasticity and excitability."@en ;
  dc:source "Medical Subject Headings 2014" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:2749
  skos:prefLabel "ubiquitina-proteína ligasa"@es, "ubiquitin-protein ligase"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:219107 .

nalt:219107
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:prefLabel "complejo promotor de la anafase"@es, "anaphase promoting complex"@en ;
  skos:altLabel "anaphase-promoting complex/cyclosome"@en, "anaphase-promoting complex-cyclosome"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:hiddenLabel "anaphase-promoting complex"@en, "anaphase-promoting-complex"@en ;
  skos:broader nalt:2749 ;
  skos:definition nalt:219107_def ;
  ns0:marc001 "62972" ;
  dc:modified "2020-05-01"^^xsd:date ;
  dc:created "2014-06-19"^^xsd:date .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .