@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

nalt:146200
  skos:prefLabel "receptor de la proteína-tirosina quinasa"@es, "receptor protein-tyrosine kinase"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:222853 .

nalt:223390
  skos:prefLabel "receptores de la hormona gastrointestinal"@es, "gastrointestinal hormone receptors"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:222853 .

nalt:222853_def
  rdf:value "Receptor de superficie celular que interviene en la regulación del crecimiento y la diferenciación celular. Es específico para el factor de crecimiento epidérmico y los péptidos relacionados con este, incluidos el factor de crecimiento transformador alfa, la anfirregulina y el factor de crecimiento similar al factor de crecimiento epidérmico de unión a heparina. La unión del ligando al receptor estimula su actividad intrínseca de tirosina quinasa y la rápida internalización del complejo receptor-ligando en la célula."@es, "A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for epidermal growth factor and EGF related peptides including transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell."@en ;
  dc:source "Medical Subject Headings 2014" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

<https://lod.nal.usda.gov/naltv#Chemical>
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:222853
  skos:hiddenLabel "epidermal-growth-factor-receptor"@en, "epidermal-growth-factor-receptors"@en, "epidermal-growth-factor receptor"@en, "epidermal-growth factor receptors"@en, "epidermal-growth factor receptor"@en, "epidermal growth factor receptor"@en ;
  skos:altLabel "erbB-1 proto-oncogene protein"@en, "EGF receptor"@en, "epidermal growth factor-urogastrone receptor"@en, "transforming growth factor alpha receptor"@en, "c-erbB-1 protein"@en, "transforming-growth factor alpha receptor"@en, "transforming growth factor-alpha receptor"@en, "TGF-alpha receptor"@en, "epidermal growth factor receptor protein-tyrosine kinase"@en, "urogastrone receptor"@en, "EGFR protein"@en, "epidermal growth factor receptor kinase"@en ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:modified "2014-11-17"^^xsd:date ;
  skos:prefLabel "epidermal growth factor receptors"@en, "receptores del factor de crecimiento epidérmico"@es ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:broader nalt:146200, nalt:223390, nalt:223335 ;
  skos:definition nalt:222853_def ;
  skos:related nalt:37571 ;
  ns0:marc001 "66476" ;
  dc:created "2014-07-25"^^xsd:date .

nalt:37571
  skos:prefLabel "factor de crecimiento epidérmico"@es, "epidermal growth factor"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:222853 .

nalt:223335
  skos:prefLabel "receptores de péptidos"@es, "peptide receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:222853 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .