@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .

nalt:146200
  skos:prefLabel "receptor de la proteína-tirosina quinasa"@es, "receptor protein-tyrosine kinase"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:222855 .

nalt:294108
  skos:prefLabel "proteínas del sustrato receptor de insulina"@es, "insulin receptor substrate proteins"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:related nalt:222855 .

nalt:222855
  skos:prefLabel "insulin receptors"@en, "receptores de insulina"@es ;
  skos:altLabel "insulin receptor protein-tyrosine kinase"@en, "insulin receptor beta subunit"@en, "insulin-dependent tyrosine protein kinase"@en, "insulin receptor alpha chain"@en, "insulin receptor beta chain"@en, "insulin receptor alpha subunit"@en ;
  skos:hiddenLabel "insulin-receptor"@en, "insulin receptor"@en, "insulin receptor protein-tyrosine kinases"@en, "insulin-receptors"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  ns0:marc001 "68379" ;
  skos:broader nalt:146200, nalt:223462 ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:modified "2017-03-02"^^xsd:date ;
  skos:related nalt:32965, nalt:294108 ;
  dc:created "2014-07-25"^^xsd:date ;
  skos:narrower nalt:222943 ;
  skos:definition nalt:222855_def .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:222943
  skos:prefLabel "receptor relacionado con el receptor de insulina"@es, "insulin receptor-related receptor"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:broader nalt:222855 .

nalt:223462
  skos:prefLabel "receptores de hormonas pancreáticas"@es, "pancreatic hormone receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:222855 .

nalt:222855_def
  rdf:value "Receptor de insulina de la superficie celular, compuesto de un tetrámero de dos subunidades alfa y dos subunidades beta derivadas de la división de una única proteína precursora. Contiene un dominio intrínseco de tirosina quinasa localizado en la subunidad beta. Su activación mediante insulina produce numerosos cambios metabólicos, incluida una absorción mayor de glucosa en el hígado, los músculos y el tejido adiposo."@es, "A cell surface receptor for insulin. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic tyrosine kinase domain that is located within the beta subunit. Activation of the receptor by insulin results in numerous metabolic changes including increased uptake of glucose into the liver, muscle, and adipose tissue."@en ;
  dc:source "Medical Subject Headings 2014" ;
  a ns0:Definition .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:32965
  skos:prefLabel "insulina"@es, "insulin"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:222855 .