@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .

nalt:236824
  skos:prefLabel "quimiocina CXCL11"@es, "chemokine CXCL11"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:related nalt:243568 .

nalt:243568
  skos:altLabel "C-X-C chemokine receptor type 3"@en, "MIG-R (Mig receptor)"@en, "CD183 antigen"@en, "chemokine (C-X-C) receptor 3"@en, "CKR-L2"@en, "GPR9 (G-protein coupled receptor 9)"@en, "CXCR3-B"@en, "interferon-inducible protein 10 receptor"@en, "chemokine (C-X-C motif) receptor 3"@en, "CXC chemokine receptor 3"@en, "IP-10 receptor"@en, "CXCR3-A"@en, "CMKAR3"@en, "I-TAC receptor"@en ;
  skos:hiddenLabel "CXCR3-receptor"@en, "CXCR3 receptors"@en, "CXC-R3"@en, "CD183 antigens"@en, "CXCR-3"@en ;
  skos:definition nalt:243568_def ;
  ns0:marc001 "65663" ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:related nalt:236823, nalt:236822, nalt:236824, nalt:236818 ;
  dc:modified "2015-11-16"^^xsd:date ;
  a ns0:Chemical, skos:Concept ;
  skos:prefLabel "receptor CXCR3"@es, "CXCR3 receptor"@en ;
  skos:broader nalt:243407 ;
  dc:created "2015-03-10"^^xsd:date .

nalt:236818
  skos:prefLabel "quimiocina CXCL4"@es, "chemokine CXCL4"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:243568 .

nalt:236822
  skos:prefLabel "quimiocina CXCL9"@es, "chemokine CXCL9"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:243568 .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:243568_def
  rdf:value "El antígeno CD183 es un receptor acoplado a la proteína G con selectividad para tres quimiocinas, denominadas proteína 10 inducible por interferón gamma (IP-10), monocina inducida por interferón gamma (MIG) y quimiotaxina alfa de linfocito T inducible por interferón (I-TAC). La unión de las quimiocinas al antígeno CD183 induce respuestas celulares que intervienen en el tránsito de leucocitos y, especialmente, en la activación de integrinas, la activación quimiotáctica y cambios citoesqueléticos. La inhibición mediante Bordetella pertussis sugiere que la proteína G heterotrimérica de la subclase Gi se acopla al antígeno CD183. Una característica distintiva de este antígeno es su prominente expresión en las células T efectoras/de memoria cultivadas in vitro y en las células T presentes en muchos tipos de tejidos inflamados. Además, las quimiocinas IP-10, MIG y I-TAC son producidas comúnmente por células locales en lesiones de naturaleza inflamatoria, lo que indica que el antígeno CD183 y sus quimiocinas participan en la atracción de células inflamatorias."@es, "CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells."@en ;
  dc:source "National Cancer Institute Thesaurus" ;
  a ns0:Definition .

nalt:236823
  skos:prefLabel "quimiocina CXCL10"@es, "chemokine CXCL10"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:243568 .

nalt:243407
  skos:prefLabel "receptores de quimiocinas"@es, "chemokine receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:243568 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .