@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:243588_def
  rdf:value "Receptor que comparte características con los receptores acoplados a la proteína G. Es un receptor de la quimiocina CXC PBSF/SDF1 y funciona como correceptor del VIH-1. Es expresado ampliamente en los sistemas inmunológico y nervioso central y puede mediar la migración de leucocitos en reposo y progenitores hematopoyéticos en respuesta a la quimiocina SDF1. La quimiocina PBSF/SDF1 y el receptor CXCR4 definen un sistema de señalización de vascularización de órganos."@es, "CXCR4 shares features common to G protein coupled receptors. CXCR4 is a receptor for the CXC chemokine PBSF/SDF1 and functions as a co-receptor for HIV-1. CXCR4 is broadly expressed in the immune and the central nervous systems and can mediate migration of resting leukocytes and hematopoietic progenitors in response to SDF1. PBSF/SDF1 and CXCR4 define a signaling system for organ vascularization."@en ;
  dc:source "National Cancer Institute Thesaurus" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:243588
  a skos:Concept, <https://lod.nal.usda.gov/naltv#Chemical> ;
  skos:altLabel "neuropeptide Y receptor Y3"@en, "chemokine (C-X-C motif) receptor 4"@en, "LESTR (leukocyte-derived seven transmembrane domain receptor)"@en, "LPS-associated protein 3"@en, "fusin"@en, "CD184 antigen"@en, "lipopolysaccharide-associated protein 3"@en, "SDF-1 (stromal cell-derived factor 1 receptor)"@en, "chemokine (C-X-C) receptor 4"@en, "seven-transmembrane-segment receptor, spleen"@en, "LAP-3 protein"@en, "C-X-C chemokine receptor type 4"@en, "SDF1-PBSF receptor"@en, "PSSF receptor (pre-B cell growth-stimulating factor receptor)"@en, "CXC chemokine receptor 4"@en, "SDF-1 receptor"@en, "LESTR receptor"@en ;
  skos:hiddenLabel "CD184 antigens"@en, "CXCR4 receptors"@en, "NPY3R protein"@en, "NPYR protein"@en, "LAP3 protein"@en, "WHIM receptor (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome receptor)"@en, "CXCR4-receptor"@en, "NPYRL protein"@en ;
  skos:prefLabel "CXCR4 receptor"@en, "receptor CXCR4"@es ;
  skos:definition nalt:243588_def ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:created "2015-03-10"^^xsd:date ;
  skos:broader nalt:243407 ;
  ns0:marc001 "65664" ;
  skos:related nalt:236825 ;
  dc:modified "2015-11-16"^^xsd:date .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:236825
  skos:prefLabel "quimiocina CXCL12"@es, "chemokine CXCL12"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:243588 .

nalt:243407
  skos:prefLabel "receptores de quimiocinas"@es, "chemokine receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:243588 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .