@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:255798
  skos:prefLabel "inhibidores de la topoisomerasa"@es, "topoisomerase inhibitors"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:related nalt:262750 .

nalt:262750
  skos:related nalt:255798, nalt:34181 ;
  skos:definition nalt:262750_def ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:broader nalt:262755, nalt:3816 ;
  dc:created "2015-10-07"^^xsd:date ;
  skos:prefLabel "etoposide"@en, "etopósido"@es ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  ns0:marc001 "66624" ;
  dc:modified "2016-02-10"^^xsd:date .

nalt:262755
  skos:prefLabel "podofilotoxina"@es, "podophyllotoxin"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:262750 .

nalt:3816
  skos:prefLabel "agentes antineoplásicos"@es, "antineoplastic agents"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:262750 .

nalt:262750_def
  rdf:value "Derivado semisintético de la podofilotoxina que presenta actividad antitumoral. Inhibe la síntesis del ADN mediante la formación de un complejo con la topoisomerasa II y el ADN, que causa rupturas en el ADN bicatenario e impide la reparación por medio de la ligadura de la topoisomerasa II. La acumulación de rupturas en el ADN evita la entrada a la fase mitótica de la división celular y conduce a la muerte celular. El etopósido actúa principalmente en las fases G2 y S del ciclo celular."@es, "A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle."@en ;
  dc:source "Medical Subject Headings 2015" ;
  a ns0:Definition .

nalt:34181
  skos:prefLabel "daño al ADN"@es, "DNA damage"@en ;
  a ns0:Topic, skos:Concept ;
  skos:related nalt:262750 .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .