@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:23427
  skos:prefLabel "permeabilidad de la membrana"@es, "membrane permeability"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:271059 .

nalt:23048
  skos:prefLabel "cationes"@es, "cations"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:related nalt:271059 .

nalt:21103
  skos:prefLabel "canales iónicos"@es, "ion channels"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:271059 .

nalt:271059_def
  rdf:value "Amplio grupo de canales catiónicos con seis dominios transmembranales que se hallan en los organismos eucariontes eucariotas. Dado que la función que desempeñan en la percepción sensorial es diversa, se clasifican de acuerdo con la homología de sus secuencias. Presentan sensibilidades iónica y al voltaje reducidas. Deben su nombre a un mutante del género Drosophila que presentaba potenciales de receptor transitorios en respuesta a la luz. Los subgrupos TRPC, TRPV y TRPM comparten un motivo de 25 aminoácidos en el que se encuentra una caja TRP (EWKFAR), en la región carboxiterminal (C-terminal) próxima al sexto segmento transmembranal (S6). Los subgrupos TRPC, TRPV y TRPN presentan repeticiones idénticas a las de la anquirina. Algunos están asociados funcionalmente a la tirosina quinasa o a las fosfolipasas tipo C."@es, "A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with sensation is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a Drosophila mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. Ankyrin repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with tyrosine kinase or type C phospholipases."@en ;
  dc:source "Medical Subject Headings 2016" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:47612
  skos:prefLabel "transporte de iones"@es, "ion transport"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:271059 .

nalt:271059
  skos:hiddenLabel "TRP channels"@en, "TRP cation channel"@en, "transient receptor potential channel"@en, "transient receptor potential family of ion channels"@en ;
  skos:related nalt:23427, nalt:23048, nalt:47612 ;
  a skos:Concept, <https://lod.nal.usda.gov/naltv#Chemical> ;
  ns0:marc001 "79409" ;
  skos:prefLabel "canales receptores transitorios de potencial"@es, "transient receptor potential channels"@en ;
  skos:broader nalt:21103 ;
  skos:altLabel "TRP cation channels"@en, "TRP membrane proteins"@en, "transient receptor potential (TRP) channels"@en ;
  dc:created "2016-01-27"^^xsd:date ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:narrower nalt:324959 ;
  dc:modified "2018-10-03"^^xsd:date ;
  skos:definition nalt:271059_def .

nalt:324959
  skos:prefLabel "receptores de potencial transitorio vaniloide"@es, "transient receptor potential vanilloid channels"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:broader nalt:271059 .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .