@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

nalt:278704_def
  rdf:value "Tipo de mutación en la que el producto del gen alterado cumple una nueva función molecular o presenta un nuevo patrón de expresión de genes. Suele ser dominante o semidominante."@es, "A type of mutation in which the altered gene product possesses a new molecular function or a new pattern of gene expression. Gain-of-function mutations are almost always dominant or semidominant."@en ;
  dc:source "National Cancer Institute, eMICE, Glossary" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:42566
  skos:prefLabel "sobreexpresión genética"@es, "gene overexpression"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:278704 .

nalt:278705
  skos:prefLabel "mutación de pérdida de función"@es, "loss-of-function mutation"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:278704 .

nalt:7777
  skos:prefLabel "mutación"@es, "mutation"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:narrower nalt:278704 .

<https://lod.nal.usda.gov/naltv#Topic>
  rdfs:label "Topic"@en ;
  a owl:Class .

nalt:278704
  skos:hiddenLabel "gain of function mutations"@en, "gain-of-function mutations"@en, "gain of function mutation"@en, "gain of function"@en, "gain-of-function"@en ;
  skos:broader nalt:7777 ;
  ns0:marc001 "76947" ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:created "2016-05-23"^^xsd:date ;
  a skos:Concept, ns0:Topic ;
  skos:prefLabel "mutación de ganancia de función"@es, "gain-of-function mutation"@en ;
  skos:related nalt:42566, nalt:278705 ;
  dc:modified "2016-11-14"^^xsd:date ;
  skos:definition nalt:278704_def .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .