@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

nalt:16459743
  skos:prefLabel "toxicología computacional"@es, "computational toxicology"@en ;
  a skos:Concept ;
  skos:narrower nalt:28890315 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:28890315_def
  rdf:value "Prueba alternativa a la prueba de dosis letal media (LD50) en la que se utilizan animales para efectuar pruebas de toxicidad aguda. A estos se les administra de uno en uno una dosis de un fármaco o sustancia tóxica. Si un animal sobrevive, se aumenta la dosis para el siguiente; si muere, se reduce la dosis para determinar el nivel de toxicidad."@es, "This test is an alternative to the Median Lethal Dose (LD50) test in which animals are used for acute toxicity testing. Animals are dosed one at a time with a drug or toxic substance. If an animal survives, the dose for the next animal is increased; if it dies, the dose is decreased to determine toxicity level."@en ;
  dc:source "Based upon Bruce R. D. (1985). An up-and-down procedure for acute toxicity testing. Fundamental and applied toxicology : official journal of the Society of Toxicology, 5(1), 151–157. " ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:28890315
  a skos:Concept ;
  skos:inScheme <https://lod.nal.usda.gov/nalt>, <https://lod.nal.usda.gov/nalt-awic> ;
  skos:definition nalt:28890315_def ;
  dc:created "2023-04-03"^^xsd:date ;
  skos:prefLabel "procedimiento de subida y bajada (UDP)"@es, "up-and-down procedure (UDP)"@en ;
  dc:modified "2024-05-04"^^xsd:date ;
  skos:broader nalt:16459743 ;
  ns0:marc001 "28890315" .