@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:291499
  skos:related nalt:291508, nalt:291300, nalt:146229 ;
  skos:altLabel "target of rapamycin kinases"@en, "TOR (target of rapamycin) kinases"@en, "rapamycin target proteins"@en ;
  skos:definition nalt:291499_def ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:hiddenLabel "mTOR kinases"@en, "mTOR kinase"@en, "TOR kinases"@en, "TOR kinase"@en ;
  dc:modified "2017-11-10"^^xsd:date ;
  dc:created "2017-02-06"^^xsd:date ;
  skos:broader nalt:217155 ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  ns0:marc001 "84113" ;
  skos:prefLabel "target of rapamycin proteins"@en, "proteínas de la diana de rapamicina"@es .

nalt:291508
  skos:prefLabel "vías de señalización de la diana de rapamicina"@es, "target of rapamycin signaling pathways"@en ;
  a ns0:Topic, skos:Concept ;
  skos:related nalt:291499 .

nalt:291499_def
  rdf:value "Serina treonina cinasa que controla una amplia gama de procesos celulares relativos al crecimiento. La proteína es denominada como la diana de rapamicina debido al descubrimiento de que el sirolimus, conocido comúnmente como rapamicina, forma un complejo inhibidor con la proteína 1A de unión a tracolimus, que bloquea la acción de su actividad enzimática."@es, "A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of rapamycin due to the discovery that sirolimus (commonly known as rapamycin) forms an inhibitory complex with tacrolimus binding protein 1A that blocks the action of its enzymatic activity."@en ;
  dc:source "Medical Subject Headings 2017" ;
  a ns0:Definition .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:217155
  skos:prefLabel "péptidos y proteínas de señalización intracelular"@es, "intracellular signaling peptides and proteins"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:291499 .

nalt:291300
  skos:prefLabel "rapamicina"@es, "rapamycin"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:291499 .

nalt:146229
  skos:prefLabel "proteína-serina-treonina quinasas"@es, "protein-serine-threonine kinases"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:291499 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .