@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:294108_def
  rdf:value "Grupo de proteínas de señalización estructuralmente relacionadas, fosforiladas por la proteína tirosina quinasa receptora de insulina. Comparten un dominio N-terminal homólogo a la pleckstrina, que es un dominio de unión a la fosfotirosina que interactúa con el receptor de insulina fosforilado, es decir, un dominio C-terminal rico en tirosina. Luego de la fosforilación de la tirosina, interactúan con proteínas específicas que contienen el dominio SH2 y que intervienen en la señalización del receptor de insulina."@es, "A structurally-related group of signaling proteins that are phosphorylated by the insulin receptor protein-tyrosine kinase. The proteins share an N-terminal pleckstrin homology domain, a phosphotyrosine-binding domain that interacts with the phosphorylated insulin receptor, and a C-terminal tyrosine-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 domain containing proteins that are involved in insulin receptor signaling."@en ;
  dc:source "Medical Subject Headings 2017" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:294108
  skos:hiddenLabel "insulin receptor substrate"@en, "insulin receptor substrate 2"@en, "insulin receptor substrate 1"@en, "insulin receptor substrate 3"@en, "insulin receptor-substrate proteins"@en, "insulin receptor substrate-3"@en, "insulin receptor substrates"@en, "insulin receptor substrate-1"@en, "insulin receptor substrate-2"@en, "insulin-receptor-substrate proteins"@en, "insulin receptor substrate 4"@en, "insulin receptor substrate-4"@en, "insulin-receptor-substrate protein"@en, "insulin-receptor-substrate-1"@en, "insulin-receptor-substrate-3"@en, "insulin-receptor-substrate-2"@en, "insulin-receptor-substrate-4"@en, "insulin receptor substrate protein"@en, "IRS signaling adaptor proteins"@en ;
  skos:prefLabel "insulin receptor substrate proteins"@en, "proteínas del sustrato receptor de insulina"@es ;
  skos:related nalt:222855 ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  ns0:marc001 "82067" ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:created "2017-03-02"^^xsd:date ;
  skos:broader nalt:223061 ;
  skos:definition nalt:294108_def ;
  dc:modified "2017-11-10"^^xsd:date .

nalt:222855
  skos:prefLabel "receptores de insulina"@es, "insulin receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:related nalt:294108 .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:223061
  skos:prefLabel "proteínas adaptadoras transductoras de señales"@es, "signal transducing adaptor proteins"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:294108 .