@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .

nalt:322237
  skos:hiddenLabel "low density-lipoprotein-receptors"@en, "low density lipo-protein receptor"@en, "low-density-lipoprotein-receptors"@en, "low density lipoprotein receptor"@en, "lipoprotein LDL-receptors"@en, "LDL receptor"@en, "lipoprotein-LDL receptors"@en, "low-density-lipoprotein-receptor"@en, "low density lipo-protein receptors"@en, "lipoprotein LDL receptor"@en ;
  skos:definition nalt:322237_def ;
  dc:created "2018-07-11"^^xsd:date ;
  a skos:Concept, <https://lod.nal.usda.gov/naltv#Chemical> ;
  skos:broader nalt:322233 ;
  skos:altLabel "lipoprotein LDL receptors"@en, "LDL receptors"@en, "LDL (low density lipoprotein) receptors"@en ;
  dc:modified "2018-11-14"^^xsd:date ;
  skos:prefLabel "receptores de lipoproteínas de baja densidad"@es, "low density lipoprotein receptors"@en ;
  ns0:marc001 "88470" ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:322237_def
  rdf:value "Receptores que se hallan en la membrana plasmática de las células no hepáticas y que se unen específicamente al colesterol LDL. Se localizan en regiones especializadas denominadas vesículas recubiertas. La hipercolesterolemia es causada por un defecto genético alélico que puede ser de tres tipos: 1) receptores que no se unen a las LDL, 2) receptores con unión reducida a las LDL y 3) receptores que se unen normalmente, pero sin internalización de las LDL. Por lo tanto, la entrada del colesterol en la célula se ve afectada y el colesterol no produce la retroalimentación intracelular en la 3-hidroxi-3-metilglutaril-CoA reductasa."@es, "Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking."@en ;
  dc:source "Medical Subject Headings 2018" ;
  a ns0:Definition .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:322233
  skos:prefLabel "receptores de lipoproteínas"@es, "lipoprotein receptors"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:narrower nalt:322237 .