@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .

nalt:329078
  skos:prefLabel "sistemas CRISPR-Cas"@es, "CRISPR-Cas systems"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:329081 .

nalt:329079
  skos:prefLabel "endonucleasas asociadas a CRISPR"@es, "CRISPR-associated endonucleases"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:329081 .

<https://lod.nal.usda.gov/naltv#Chemical>
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:329081
  skos:related nalt:329078 ;
  dc:modified "2019-11-25"^^xsd:date ;
  skos:prefLabel "CRISPR-associated endonuclease 9"@en, "CRISPR proteína asociada 9"@es ;
  a skos:Concept, <https://lod.nal.usda.gov/naltv#Chemical> ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  skos:altLabel "Cas9 protein"@en, "Cas9 endonuclease"@en, "Cas9 enzyme"@en ;
  ns0:marc001 "9813982864200041" ;
  skos:definition nalt:329081_def ;
  skos:broader nalt:329079 ;
  ns0:marc001previous "93682" ;
  dc:created "2019-03-25"^^xsd:date ;
  skos:hiddenLabel "CRISPR-associated endonuclease-9"@en .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:329081_def
  rdf:value "Endodeoxirribonucleasa guiada por ARN que se asocia a secuencias de CRISPR en la bacteria Streptococcus pyogenes y otras bacterias en las que interviene en una función inmune adaptativa para adherir ADN extraño complementario a ARN guías. Estructuralmente, está compuesta por un módulo de hélice alfa y un módulo de nucleasa conectado por una única hélice. El módulo de nucleasa contiene dos dominios enzimáticos: RuvC, que corta la cadena de ADN no objetivo, y un dominio de nucleasa HNH, que corta la cadena objetivo."@es, "An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand."@en ;
  dc:source "Taken in part from: Medical Subject Headings" ;
  a ns0:Definition .