@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .

nalt:10250
  skos:prefLabel "lovastatina"@es, "lovastatin"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:341360 .

nalt:85017
  skos:prefLabel "colesterol de lipoproteína de baja densidad"@es, "low density lipoprotein cholesterol"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:related nalt:341360 .

<https://lod.nal.usda.gov/naltv#Chemical>
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:341360
  skos:hiddenLabel "MK-733"@en, "simvastatins"@en, "synvinolin"@en, "zocor"@en ;
  skos:prefLabel "simvastatina"@es, "simvastatin"@en ;
  dc:modified "2020-10-29"^^xsd:date ;
  skos:related nalt:85017 ;
  skos:broader nalt:10250 ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  dc:created "2020-07-15"^^xsd:date ;
  ns0:marc001 "95688" ;
  a skos:Concept, ns0:Chemical ;
  skos:definition nalt:341360_def .

nalt:341360_def
  rdf:value "Derivado de la lovastatina y un potente inhibidor competitivo de la 3-hidroxi-3-metilglutaril-coenzima-A reductasa (hidroximetilglutaril CoA reductasas), que constituye la enzima limitante en la biosíntesis del colesterol. Además, puede intervenir en la producción de hormonas esteroides. Debido a la inducción de receptores de LDL hepático, incrementa la descomposición del colesterol LDL."@es, "A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethylglutaryl CoA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol."@en ;
  dc:source "Medical Subject Headings" ;
  a ns0:Definition .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .