@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .

<https://lod.nal.usda.gov/naltv#Chemical>
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:6456
  skos:prefLabel "alcaloides del opio"@es, "opium alkaloids"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:8452 .

nalt:8452_def
  rdf:value "Derivado del opioide alcaloide de la tebaína que es más potente y tiene efecto analgésico más duradero que el de la morfina. Parece actuar como agonista parcial en receptores de opioides mu y kappa y como antagonista en receptores delta. Se ha sugerido que la ausencia de actividad delta-agonista es la causa de la observación de que probablemente no se desarrolle tolerancia a la buprenorfina con el uso prolongado."@es, "A derivative of the opioid alkaloid thebaine that is a more potent and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use."@en ;
  dc:source "Medical Subject Headings 2012" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:2318
  skos:prefLabel "analgésicos"@es, "analgesics"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:8452 .

nalt:8452
  skos:hiddenLabel "buprenorphine HCl"@en ;
  skos:prefLabel "buprenorphine"@en, "buprenorfina"@es ;
  dc:created "2006-01-19"^^xsd:date ;
  skos:broader nalt:2318, nalt:6456 ;
  skos:inScheme <https://lod.nal.usda.gov/nalt>, <https://lod.nal.usda.gov/nalt-awic> ;
  ns0:marc001 "6156" ;
  skos:definition nalt:8452_def ;
  a skos:Concept, ns0:Chemical ;
  skos:exactMatch <http://id.loc.gov/authorities/subjects/sh85018028> ;
  skos:altLabel "buprenorphine hydrochloride"@en ;
  dc:modified "2016-06-30"^^xsd:date .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .