@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:196319
  skos:prefLabel "histona deacetilasa"@es, "histone deacetylase"@en ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:narrower nalt:343157 .

nalt:343157_def
  rdf:value "Familia homóloga de enzimas reguladoras relacionadas estructuralmente con la proteína de acoplamiento reguladora de información silente 2 (Sir2) encontrada en el hongo Saccharomyces cerevisiae. Las sirtuinas contienen una región núcleo catalítica central que une los NAD. Varias sirtuinas utilizan los NAD para desacetilizar proteínas como las histonas y se clasifican como histona desacetilasas del grupo III. Otras sirtuinas, que utilizan los NAD para transferir ADP-ribosa a las proteínas, se categorizan como mono ADP ribosa transferasas, mientras que un tercer grupo de sirtuinas parece tener actividades desacetilasa y ADP ribosa transferasa."@es, "A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as histones and are categorized as Group III histone deacetylases. Several other sirtuin members utilize NAD to transfer ADP-ribose to proteins and are categorized as mono ADP-ribose transferases, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities."@en ;
  dc:source "Medical Subject Headings" ;
  a <https://lod.nal.usda.gov/naltv#Definition> .

nalt:343157
  skos:altLabel "sirtuin 2"@en, "sirtuin 3"@en ;
  skos:inScheme <https://lod.nal.usda.gov/nalt> ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  skos:prefLabel "sirtuinas"@es, "sirtuins"@en ;
  skos:hiddenLabel "sirtuin-1"@en, "sirtuin-3"@en, "sirtuin"@en, "sirtuin 1"@en, "sirtuin-2"@en ;
  skos:broader nalt:196319 ;
  skos:definition nalt:343157_def ;
  ns0:marc001 "95967" ;
  dc:created "2020-09-14"^^xsd:date ;
  dc:modified "2020-10-29"^^xsd:date .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .