@prefix nalt: <https://lod.nal.usda.gov/nalt/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ns0: <https://lod.nal.usda.gov/naltv#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

nalt:18995
  skos:prefLabel "enfermedades por prión"@es, "prion diseases"@en ;
  a <https://lod.nal.usda.gov/naltv#Topic>, skos:Concept ;
  skos:related nalt:40965 .

nalt:40965
  skos:definition nalt:40965_def ;
  skos:altLabel "prion proteins"@en, "PrP proteins"@en ;
  skos:inScheme <https://lod.nal.usda.gov/nalt>, <https://lod.nal.usda.gov/nalt-core> ;
  skos:hiddenLabel "prion protein"@en, "prion"@en, "PRP protein"@en, "prion seeds"@en ;
  skos:broader nalt:876 ;
  skos:exactMatch <http://id.cabi.org/cabt/94717>, <http://id.agrisemantics.org/gacs/C15668>, <http://id.loc.gov/authorities/subjects/sh86005911>, <http://aims.fao.org/aos/agrovoc/c_36165>, <http://id.cabi.org/cabt/94653> ;
  skos:narrower nalt:217658, nalt:59646 ;
  skos:related nalt:18995, nalt:1988 ;
  dc:created "2006-01-19"^^xsd:date ;
  skos:prefLabel "prions"@en, "priones"@es ;
  a <https://lod.nal.usda.gov/naltv#Chemical>, skos:Concept ;
  ns0:marc001 "30096" ;
  dc:modified "2015-12-30"^^xsd:date .

nalt:40965_def
  rdf:value "Pequeñas partículas infecciosas proteináceas que resisten a la inactivación por los procedimientos que modifican a los ácidos nucleicos y que contienen una isoforma anormal de una proteína celular que es un componente importante y necesario. La isoforma anormal (precursora) es PrPSc y la isoforma celular PrPC. La secuencia primaria de aminoácidos de las dos isoformas es idéntica. Entre las enfermedades humanas producidas por los priones se encuentran la scrapie, la encefalopatía espongiforme bovina, y el síndrome de Creutzfeldt-Jakob."@es, "Small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc; the cellular isoform is PrPC. The primary amino acid sequence of the two isoforms is identical. Among diseases caused by prions are scrapie, bovine spongiform encephalopathy, and Creuzfeldt-Jakob Syndrome."@en ;
  dc:source "Medical Subject Headings" ;
  a ns0:Definition .

ns0:Chemical
  rdfs:label "Chemical"@en ;
  a owl:Class .

nalt:876
  skos:prefLabel "proteínas"@es, "proteins"@en ;
  a ns0:Product, ns0:Chemical, skos:Concept ;
  skos:narrower nalt:40965 .

nalt:217658
  skos:prefLabel "proteínas priónicas celulares (PrPc)"@es, "PrPC proteins"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:broader nalt:40965 .

nalt:59646
  skos:prefLabel "proteínas PrPSc"@es, "PrPSc proteins"@en ;
  a ns0:Chemical, skos:Concept ;
  skos:broader nalt:40965 .

<https://lod.nal.usda.gov/nalt>
  rdfs:label "NALT Full"@en ;
  a skos:ConceptScheme .

nalt:1988
  skos:prefLabel "patógenos alimentarios"@es, "food pathogens"@en ;
  a ns0:Topic, skos:Concept ;
  skos:related nalt:40965 .